Studies on lipogenesis in hereditary obese-hyperglycemic mice (KK strain).

General survey of diabetic features of yellow KK mice.

Yellow KK mice, carrying the yellow obese gene (Ay), developed marked adiposity and diabetic symptoms in comparison with their control littermates, black KK mice. The blood glucose and circulating insulin levels were increased progressively from 5 weeks of age in yellow KK mice. Age dependent alterlations were also observed in pancreas and kidney. Namely, degranulation and glycogen infiltration...

Obesity, Diabetes and Leptin: Lessons Learned from Obese Hyperglycemic Mice

The recent epidemic nature of obesity and association of obesity with the development of type 2 diabetes demands dissection of the pathophysiology of this morbid disorder which is essential for better understanding of the process of evolution of insulin resistance. Different animal models have been used to explore the mechanism linking obesity to insulin resistance and type 2 diabetes. The disc...

Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain.

KK obese mice exhibit a multigenic syndrome of moderate obesity, hyperinsulinemia and hyperglycemia. Here we show that the syndrome is accompanied by a marked elevation of leptin protein in adipose tissue, as well as leptin levels in serum, which corresponds with the degree of obesity. The cDNA sequence of leptin is normal in KK mice, whereas three nucleotide polymorphisms were found in the cDN...

Imperfect homeothermia in the hereditary obese-hyperglycemic syndrome of mice.

Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice

Carlsson, Per-Ola, Arne Andersson, and Leif Jansson. Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E594–E601, 1998.—This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had...